Today we start our new series of General Pharmacology Principles. The first topic is “Intro to Pharmacodynamics.” I start by discussing the different MOA a drug can work by and then having a deeper look at receptors (01:54). Then I look at the Law of Mass Action and how this applies to receptor affinity (10:32). This brings me to a very important LO which examines the dose-effect relationships of drugs with a look a at some really important graphs (13:42). There is only one SAQ to review at the end (29:56). Next episode I will go through ‘Intro to PK.’ Thanks for listening! As always if you have any feedback let me know @ anirudh@sweetdreamsanaesthesia.com

In today’s episode I cover pharmacokinetics. Sorry for the delay but this was a big episode to record. I go through the ADME structure in order starting with absorption (04:21), distribution (15:34), metabolism (23:36) and elimination (30:37). Then I briefly look at intravenous infusion kinetics (35:33) followed by the past SAQ’s (41:25). There are so many SAQ’s to go through and for the purposes of time I have just looked at a select view. Next episode I will go through ‘Drug Variability and Interactions.’ Thanks for listening! As always if you have any feedback let me know @ anirudh@sweetdreamsanaesthesia.com

Today’s episode is huge!! I go through all the little things not covered in PK or PD with regards to general pharmacology. First, I go through broadly drug preparation and packaging within pharmaceutics (01:18) followed by isomerism (08:11). Then I move on to drug variability starting off with some definitions (19:05) and then moving on to changes in PD and PK among different physiological states (22:47) and pathological states (38:29). Lastly, I look at a classification for adverse drug reactions (44:20). As always, I finish with a look at the past SAQs (48:13). There were so many to go through here! Thanks for listening! As always if you have any feedback let me know

Happy New Year! I’m joined today with a very special guest and current primary exam examiner Dr Anthony. In this episode we take a in depth look at the Pharmacokinetics of Propofol TCI. Anthony has curated this talk over multiple years and starts of by explaining the main equations you should know (05:35). We then integrate these equations into the classic Propofol Cp vs Time graph (11:52). This leads us on to talking about the compartment model (20:11) and how this applies to the ‘Marsh’ TCI model (23:25). To help understand the concepts of rate constants (k) Anthony uses his bucket analogy (27:27). Then we apply this knowledge to understand effect site targeting (Ce) and run through some examples of differences in age (41:30) and weight (66:05). Finally, we finish with a brief look at the ‘Eleveld’ Model and the concept of Keo (72:40). A huge thank you to Anthony and as always if you have any feedback let me know.